gsr-1 Antibody

Code CSB-PA929815XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gsr-1 Polyclonal antibody
Uniprot No.
Target Names
gsr-1
Alternative Names
gsr-1 antibody; C46F11.2 antibody; Glutathione reductase antibody; mitochondrial antibody; GR antibody; EC 1.8.1.7 antibody; Glutathione disulfide reductase antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gsr-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr-1, required for the reduction of disulfide groups in the cuticle during molting.
Gene References into Functions
  1. the embryonic lethality of gsr-1 worms is prevented by restoring GSR-1 activity in the cytoplasm but not in mitochondria. Given the fact that the thioredoxin redox systems are dispensable in C. elegans, our data support a prominent role of the glutathione reductase/glutathione pathway in maintaining redox homeostasis in the nematode PMID: 27117030
  2. role of GSR-1 in stress tolerance and longevity PMID: 23593298
Subcellular Location
Cytoplasm. Mitochondrion.
Protein Families
Class-I pyridine nucleotide-disulfide oxidoreductase family
Tissue Specificity
Expressed at all larval stages and in adults in intestine, vulva muscle, pharynx and some cells in the tail.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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