HTZ1 Antibody

1. Study shows that the H2A.Z histone variant impacts various aspects of meiotic development adding further insight into the relevance of chromatin dynamics for accurate gametogenesis. PMID: 29853474
2. It has been found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. PMID: 28532323
3. We found that ectopic CENP-A(Cse4) is enriched at promoters that contain histone H2A.Z(Htz1) nucleosomes, but that H2A.Z(Htz1) is not required for CENP-A(Cse4) mislocalization PMID: 26982580
4. analysis suggests that Htz1 and nucleosome dynamics change in response to oleate stress. PMID: 26182431
5. identify genetic links between Thr4 and the histone variant Htz1 and show that Thr4, as well as the Ino80 chromatin remodeler, is required for activation-associated eviction of Htz1 specifically from promoters of the Thr4-dependent genes PMID: 25071213
6. nalysis of between-line variation shows the morphological effects of eliminating HTZ1 to be highly dependent on the line, which implies that HTZ1 interacts with mutations that have accumulated in the lines. PMID: 23990806
7. The results indicates a function for Htz1 in promoting nucleotide excision repair in the Htz1-containing nucleosomes by regulating the occupancy of Gcn5 on chromatin, the UV-induced histone H3 acetylation and the binding of Rad14 to damaged DNA in the nucleosomes. PMID: 23925126
8. Nucleosome-free region is critical for the targeting of multisubunit chromatin remodeler SWR1, it is not required for postrecruitment enzyme activity, which requires binding of the H2A.Z-H2B dimer. PMID: 24034247
9. Nucleosomes containing Htz1p are primarily composed of H4 K12ac and H3 K4me3 but not H3 K36me3. PMID: 22393239
10. The short forms of H2A.Z in both yeast and human cells are more loosely associated with chromatin than the full-length proteins, indicating a conserved function for the H2A.Z C-terminal tail in regulating the association of H2A.Z with nucleosomes. PMID: 22493515
11. We verified an Swr1-independent role for H2A.Z following genotoxic stress in vivo. PMID: 21901086
12. Here we have identified key functional regions located in the C-terminal docking domain in histone variant H2A.Z. PMID: 21791612
13. Data suggest that residues F32 and I109 appear to have an Htz1-specific role. PMID: 21470346
14. each Htz1 N-terminal lysine is deacetylated by Hda1 in response to benomyl and reacetylated when this agent is removed. Such active regulation suggests that acetylation plays a significant role in Htz1 function. PMID: 20952395
15. NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex. PMID: 20332092
16. HTZ1 poises repressed/basal promoters for activation through histone loss. PMID: 16239141
17. HTZ1 marks the 5' ends of both active and inactive genes in euchromatin. PMID: 16239142
18. Swc2 binds directly to and is essential for transfer of H2AZ; the C-terminal alpha-helix of H2AZ is crucial for its recognition by SWR1. PMID: 16299513
19. Htz1 may serve to mark quiescent promoters for proper activation PMID: 16344463
20. cells lacking H2A.Z required the S-phase checkpoint pathway for survival and were delayed in the induction of cyclin genes. PMID: 16382141
21. examination of role in transcription, DNA repair, chromosome stability, and limiting telomeric silencing PMID: 16543219
22. results show a role for H2A.Z acetylation in restricting silent chromatin, and reveal that acetylation of H2A.Z and H4 can contribute to a common function essential to life PMID: 16543222
23. H4 Lys 16 acetylation by SAS is required for efficient H2A.Z incorporation near telomeres. PMID: 16980580
24. the DNA sequence of 322,000 individual Saccharomyces cerevisiae nucleosomes, containing the histone variant H2A.Z, to provide a comprehensive map of H2A.Z nucleosomes in functionally important regions PMID: 17392789
25. H2A.Z and Set1 cooperate to prevent Sir-dependent repression of a large number of genes located across the genome, rather than the local effects reported previously for the individual mechanisms. PMID: 17925448
26. Global dynamics of newly constructed oligonucleosomes of conventional and variant H2A.Z histone are reported. PMID: 17996059
27. Results suggest that the initial presence of Htz1p appears to mark promoters for sustained gene expression and the recruitment of TATA-binding protein. PMID: 19273605
28. nucleosome-free region establishment is necessary for H2A.Z deposition. These studies suggest an ordered pathway for the assembly of promoter chromatin architecture PMID: 19410542
29. Data show that the variant histone, Htz1p, and its acetylation state seem to play an important role in maintaining ER retrieval pathways, suggesting a surprising link between chromatin remodeling and ER homeostasis. PMID: 19433630

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KEGG: sce:YOL012C

STRING: 4932.YOL012C