Recombinant Saccharomyces cerevisiae Histone H2A.Z (HTZ1)

1. Study shows that the H2A.Z histone variant impacts various aspects of meiotic development adding further insight into the relevance of chromatin dynamics for accurate gametogenesis. PMID: 29853474
2. It has been found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. PMID: 28532323
3. We found that ectopic CENP-A(Cse4) is enriched at promoters that contain histone H2A.Z(Htz1) nucleosomes, but that H2A.Z(Htz1) is not required for CENP-A(Cse4) mislocalization PMID: 26982580
4. analysis suggests that Htz1 and nucleosome dynamics change in response to oleate stress. PMID: 26182431
5. identify genetic links between Thr4 and the histone variant Htz1 and show that Thr4, as well as the Ino80 chromatin remodeler, is required for activation-associated eviction of Htz1 specifically from promoters of the Thr4-dependent genes PMID: 25071213
6. nalysis of between-line variation shows the morphological effects of eliminating HTZ1 to be highly dependent on the line, which implies that HTZ1 interacts with mutations that have accumulated in the lines. PMID: 23990806
7. The results indicates a function for Htz1 in promoting nucleotide excision repair in the Htz1-containing nucleosomes by regulating the occupancy of Gcn5 on chromatin, the UV-induced histone H3 acetylation and the binding of Rad14 to damaged DNA in the nucleosomes. PMID: 23925126
8. Nucleosome-free region is critical for the targeting of multisubunit chromatin remodeler SWR1, it is not required for postrecruitment enzyme activity, which requires binding of the H2A.Z-H2B dimer. PMID: 24034247
9. Nucleosomes containing Htz1p are primarily composed of H4 K12ac and H3 K4me3 but not H3 K36me3. PMID: 22393239
10. The short forms of H2A.Z in both yeast and human cells are more loosely associated with chromatin than the full-length proteins, indicating a conserved function for the H2A.Z C-terminal tail in regulating the association of H2A.Z with nucleosomes. PMID: 22493515
11. We verified an Swr1-independent role for H2A.Z following genotoxic stress in vivo. PMID: 21901086
12. Here we have identified key functional regions located in the C-terminal docking domain in histone variant H2A.Z. PMID: 21791612
13. Data suggest that residues F32 and I109 appear to have an Htz1-specific role. PMID: 21470346
14. each Htz1 N-terminal lysine is deacetylated by Hda1 in response to benomyl and reacetylated when this agent is removed. Such active regulation suggests that acetylation plays a significant role in Htz1 function. PMID: 20952395
15. NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex. PMID: 20332092
16. HTZ1 poises repressed/basal promoters for activation through histone loss. PMID: 16239141
17. HTZ1 marks the 5' ends of both active and inactive genes in euchromatin. PMID: 16239142
18. Swc2 binds directly to and is essential for transfer of H2AZ; the C-terminal alpha-helix of H2AZ is crucial for its recognition by SWR1. PMID: 16299513
19. Htz1 may serve to mark quiescent promoters for proper activation PMID: 16344463
20. cells lacking H2A.Z required the S-phase checkpoint pathway for survival and were delayed in the induction of cyclin genes. PMID: 16382141
21. examination of role in transcription, DNA repair, chromosome stability, and limiting telomeric silencing PMID: 16543219
22. results show a role for H2A.Z acetylation in restricting silent chromatin, and reveal that acetylation of H2A.Z and H4 can contribute to a common function essential to life PMID: 16543222
23. H4 Lys 16 acetylation by SAS is required for efficient H2A.Z incorporation near telomeres. PMID: 16980580
24. the DNA sequence of 322,000 individual Saccharomyces cerevisiae nucleosomes, containing the histone variant H2A.Z, to provide a comprehensive map of H2A.Z nucleosomes in functionally important regions PMID: 17392789
25. H2A.Z and Set1 cooperate to prevent Sir-dependent repression of a large number of genes located across the genome, rather than the local effects reported previously for the individual mechanisms. PMID: 17925448
26. Global dynamics of newly constructed oligonucleosomes of conventional and variant H2A.Z histone are reported. PMID: 17996059
27. Results suggest that the initial presence of Htz1p appears to mark promoters for sustained gene expression and the recruitment of TATA-binding protein. PMID: 19273605
28. nucleosome-free region establishment is necessary for H2A.Z deposition. These studies suggest an ordered pathway for the assembly of promoter chromatin architecture PMID: 19410542
29. Data show that the variant histone, Htz1p, and its acetylation state seem to play an important role in maintaining ER retrieval pathways, suggesting a surprising link between chromatin remodeling and ER homeostasis. PMID: 19433630

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KEGG: sce:YOL012C

STRING: 4932.YOL012C