HTB2 Antibody

1. The histone modification domain of Paf1 complex subunit Rtf1 directly stimulates H2B ubiquitylation through an interaction with Rad6. PMID: 27840029
2. These results indicate that eukaryotic cells respond to RNAPII arrest by deubiquitylating H2B to coordinate DNA repair and RNAPII degradation. PMID: 25136098
3. Data indicate that histone H2B repression (HBR) domain is important for FACT (consisting of Spt16/Pob3) histone chaperone activity. PMID: 24248595
4. this study provides evidence that only small levels of H2BK123ub are necessary for full levels of H3K4 and H3K79 trimethylation in vivo and points to a possible role for Chd1 in positively regulating gene expression through promoting nucleosome reassembly coupled with H2B monoubiquitination. PMID: 22549955
5. Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat. PMID: 21680712
6. Results describe a novel role for the H2B C-terminal helix in the trans-histone cross talk as a binding surface for Set1-COMPASS. PMID: 20439497
7. propose a structural model by which H2B R102 and K111 regulate the binding of the Sir complex to the nucleosome PMID: 20479120
8. Disruption of Lge1 abolished ubiquitylation of histone H2B on lysine 123 and H3 methylation on lysines 4 and 79 PMID: 19923226
9. Lge1p has roles in gene regulation independent of its participation in the Rad6p-dependent ubiquitination of H2B PMID: 15528187
10. H2B-Lys-123 ubiquitination has roles in regulation of H3-Lys-4 methylation and recruitment of RNA polymerase II PMID: 16675445
11. Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10 PMID: 17052455
12. Sgf73 provides a molecular scaffold to integrate the regulation of H2B ubiquitin levels, tethering of a gene to the NPC and export of mRNA PMID: 18488019
13. some of the biological effects of ubiquitylation of H2B are exerted via ubiquitin chains, rather than a single ubiquitin group PMID: 18562693
14. the role of Sus1 in nuclear pore complex targeting of an mRNA export complex and histone H2B deubiquitination PMID: 19269973

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KEGG: sce:YBL002W

STRING: 4932.YBL002W