HAC1 Antibody

1. Here, the authors show that a combination of inhibited translation initiation and accelerated protein degradation-both dependent on the intron-prevents the accumulation of Hac1 protein when the unfolded protein response is inactive. PMID: 27692069
2. Hac1p restored the Golgi localization of Arl1p and Imh1p inIRE1-deleted cells. Ire1p-Hac1p axis regulated Syt1p phosphorylation, which enhances Arl1p activation, recruitment of Imh1p to the Golgi, and Syt1p interaction with Arl1p. PMID: 26966233
3. Results indicate that the 5'-untranslated region (5' UTR)-intron interaction represses translation initiation on the unspliced Hac1 transcription factor mRNA. PMID: 26175153
4. Kin2 has a role in regulating HAC1 mRNA translocation, splicing, and translation PMID: 25348718
5. Our data suggest a complex mutual cross talk between the Hac1- and Gcn4-controlled networks. PMID: 23794510
6. Expression of rat Bax induces the unfolded protein response by inducing HAC1 mRNA splicing in Saccharomyces cerevisiae. PMID: 22903551
7. the splicing and the release of translational attenuation of HAC1 mRNA are separable steps PMID: 20844078
8. transcription of HAC1 is regulated through a pathway involving IRE1 PMID: 15314654
9. Gcn4p, Hac1p, and Gcn2p regulate targets of the unfolded protein response PMID: 15314660
10. Hac1p harbors a functional PEST degron and t degradation of Hac1p by the proteasome involves the E2 ubiquitin-conjugating enzyme Ubc3/Cdc34p and the SCF(Cdc4) E3 complex. PMID: 17108329
11. Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA PMID: 18180297

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KEGG: sce:YFL031W

STRING: 4932.YFL031W