hchA Antibody

Code CSB-PA511481XA01ENU
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Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12 / MC4100 / BW2952) hchA Polyclonal antibody
Uniprot No.
Target Names
hchA
Alternative Names
hchA antibody; BWG_1768 antibody; Protein/nucleic acid deglycase HchA antibody; EC 3.1.2.- antibody; EC 3.5.1.- antibody; EC 3.5.1.124 antibody; Maillard deglycase antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli (strain K12 / MC4100 / BW2952)
Immunogen
Recombinant Escherichia coli (strain K12 / MC4100 / BW2952) hchA protein
Immunogen Species
Escherichia coli (strain K12 / MC4100 / BW2952)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Plays an important role in protecting cells from carbonyl stress.
Subcellular Location
Cytoplasm.
Protein Families
Peptidase C56 family, HchA subfamily
Database Links

KEGG: ebw:BWG_1768

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