hcp-3 Antibody

Code CSB-PA335943XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans hcp-3 Polyclonal antibody
Uniprot No.
Target Names
hcp-3
Alternative Names
hcp-3 antibody; F58A4.3 antibody; Histone H3-like centromeric protein hcp-3 antibody; CENP-A homolog antibody; CeCENP-A antibody; Holocentric chromosome-binding protein 3 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans hcp-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Might promote cleavage furrow stability during cytokinesis. Not required for chromosome segregation during meiosis.
Gene References into Functions
  1. Results suggest that acetylation of soluble H4 may stimulate the initial deposition of CENP-A(HCP-3)-H4 nucleosomes. PMID: 29653589
Subcellular Location
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Protein Families
Histone H3 family
Database Links

KEGG: cel:CELE_F58A4.3

STRING: 6239.F58A4.3

UniGene: Cel.10383

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