hda Antibody

1. structural and mutational analyses of the Hda-beta clamp complex indicate that the interaction of the beta clamp with Hda controls the ability of Hda to interact with DnaA. PMID: 28168278
2. results establish a model in which interaction between DnaA Asn-44 and Hda stabilizes the association between the AAA+ domains of DnaA and Hda to facilitate DnaA-ATP hydrolysis during RIDA(regulatory inactivation of DnaA) PMID: 23679057
3. Taken together, these findings suggest that although one or more Hda functions are essential for cell viability, regulatory inactivation of DnaA may be dispensable. PMID: 22716942
4. functional DnaA-Hda interactions require a second interaction site within DnaA domain IV in addition to the AAA+ domain PMID: 21708944
5. Here, the authors demonstrate that direct and functional interaction of ADP-Hda with DnaA requires the Hda residues Ser-152, Phe-118 and Asn-122 as well as Hda Arg-153 and DnaA Arg-334. PMID: 20132442
6. data suggest the model: DnaA-ATP is hydrolyzed at a binding interface between the AAA(+) domains of DnaA and Hda; the DnaA N-terminal domain supports this interaction; the interaction of DnaA-ATP with the Hda-clamp complex occurs in a catalytic mode PMID: 15611053
7. Inactivation of active ATP-DnaA by the Hda protein and the sliding clamp of the polymerase was found to be required to prevent reinitiation and asynchrony of replication. PMID: 15939703
8. Hda inactivaes DnaA, which prevents hyperinitiation of Escherichia coli DNA replication PMID: 16041320
9. Overexpression of the Hda DnaA-related protein in Escherichia coli inhibits multiplication, affects membrane permeability, and induces the SOS response. PMID: 16321957
10. The presence of genes encoding a previously unpublished adhesin termed Hda was found in several EAEC strains isolated from Denmark, suggesting that this adhesin represents an important variant in the Afa/Dr/AAF family. PMID: 18443096
11. Hda monomerization by ADP binding promotes replicase clamp-mediated DnaA-ATP hydrolysis PMID: 18977760
12. Mutations that reduce initiation frequency from oriC suppress the growth defect of Hda-deficient cells. PMID: 19007419

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KEGG: ecj:JW5397

STRING: 316385.ECDH10B_2662