Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) HDA19 Polyclonal antibody

Uniprot No.

O22446

Target Names

HDA19

Alternative Names

HDA19 antibody; HD1 antibody; HDA1 antibody; RPD3A antibody; At4g38130 antibody; F20D10.250 antibody; Histone deacetylase 19 antibody; AtHD1 antibody; HD antibody; EC 3.5.1.98 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana HDA19 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous floral organ identity genes. Involved in negative regulation of salinity stress response. Represses the expression of stress tolerance-related genes, genes coding for late embryogenesis abundant (LEA) proteins that prevent protein aggregation, and positive regulators of abscisic acid (ABA) signaling, such as ABI5 and NAC019.

Gene References into Functions

These results reveal the presence of an MSI1-HDA19 complex that fine-tunes abscissic acid signaling in Arabidopsis. PMID: 26704384
SCL15 acts as an HDA19-associated regulator to repress embryonic traits in seedlings. PMID: 26129778
HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress. PMID: 24058159
HDA19 plays a negative role in basal defense mediated by the salicylic acid-dependent signaling pathway. PMID: 22381007
HDA6 and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19] PMID: 20930557
HDA19 may regulate gene expression involved in jasmonic acid and ethylene signaling of pathogen response in Arabidopsis.[HDA19] PMID: 15749761
Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development. PMID: 16699543
These results suggest that during germination in Arabidopsis, HDA6 and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function. PMID: 18024558
Disruption of HDA19 leads to compromised resistance, whereas its overexpression results in enhanced resistance to P. syringae. PMID: 18776063

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Subcellular Location

Nucleus. Note=excluded from the nucleolus, but associated with the condensing chromatids.

Protein Families

Histone deacetylase family, HD type 1 subfamily

Tissue Specificity

Highly expressed in leaves, stems, flowers and young siliques.

Database Links

KEGG: ath:AT4G38130

STRING: 3702.AT4G38130.1

UniGene: At.25069

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HDA19 Antibody

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