Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) HDA6 Polyclonal antibody

Uniprot No.

Q9FML2

Target Names

HDA6

Alternative Names

HDA6 antibody; RPD3B antibody; At5g63110 antibody; MDC12.7 antibody; Histone deacetylase 6 antibody; AtHDA6 antibody; EC 3.5.1.98 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana HDA6 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this effect seems to bee independent of the histone deacetylase activity. Part of the AS1 repressor complex to regulate the KNOX expression in leaf development. Binds to KNAT1, KNAT2, and KNATM chromatin. Involved in the regulation of flowering time. Forms a histone deacetylase complex with HDA5, FLD and MSI4/FVE that represses FLC gene expression to control flowering time.

Gene References into Functions

HDA6 is a general repressor of pathogen defence response and plays important roles in inhibiting and modulating the expression of pathogen-responsive genes in Arabidopsis. PMID: 28770584
HDA6 is a component of the TRB2 complex. PMID: 26857545
HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation at CG dinucleotides. PMID: 25918117
Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1) in the root tip were affected in hda6 mutation. PMID: 26143251
HDA6 and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis. PMID: 20930557
HDA6 is required for heterochromatic silencing, and the mutation results in loss of heterochromatic histone modification along with aberrant enrichment for euchromatic modification at HDA6 targets. PMID: 21552333
HDA6 plays a critical role in regulating cold acclimation process that confers freezing resistance on Arabidopsis. PMID: 21329671
HDA6-involved histone modifications modulate seed germination and the salt stress response. PMID: 20519338
reveal a futile cycle of unregulated transcription, siRNA production, and siRNA-directed DNA methylation in the absence of HDA6-mediated histone deacetylation PMID: 20516197
HDA6 erases histone acetylation as a key step in an epigenetic switch mechanism that silences rRNA genes through concerted histone and DNA modifications. PMID: 16648464
involved in jasmonate response, senescence, and flowering PMID: 18212027

Hide All

Subcellular Location

Nucleus, nucleolus. Nucleus.

Protein Families

Histone deacetylase family, HD type 1 subfamily

Tissue Specificity

Not detected in leaves, stems, flowers and young siliques.

Database Links

KEGG: ath:AT5G63110

STRING: 3702.AT5G63110.1

UniGene: At.8834

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HDA6 Antibody

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