ceh-14 Antibody

Code CSB-PA322620XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans ceh-14 Polyclonal antibody
Uniprot No.
Target Names
ceh-14
Alternative Names
ceh-14 antibody; F46C8.5Homeobox protein ceh-14 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans ceh-14 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1 and homeobox protein ceh-63, perhaps acting in concert with ceh-63. Confers thermosensory function to neurons. Required for correct AFD-mediated thermotaxis. Involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA. Regulates its own expression and also that of homeodomain ceh-17, together forming an autoregulatory loop in the ALA neuron. Required for initial pathfinding of the ALA axons, but largely dispensable for axon migration.
Gene References into Functions
  1. loss of a LIM domain in the ceh-14(ch2) allele causes a partial loss-of-function phenotype PMID: 23608457
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in the anterior AFDL/R sensory neurons and BDUL/R and ALA interneurons, and in PVT, PVQL/R, DVC, PVNL/R, PVWL/R, PVR, PHCL/R, PHAL/R and PHBL/R cells in the tail region.
Database Links

KEGG: cel:CELE_F46C8.5

STRING: 6239.F46C8.5

UniGene: Cel.18140

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