HMA2 Antibody

Code CSB-PA866035XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) HMA2 Polyclonal antibody
Uniprot No.
Target Names
HMA2
Alternative Names
HMA2 antibody; At4g30110 antibody; F6G3.140 antibody; Cadmium/zinc-transporting ATPase HMA2 antibody; EC 7.2.2.12 antibody; EC 7.2.2.21 antibody; Cadmium/zinc-transporting ATPase 3 antibody; Protein HEAVY METAL ATPASE 2 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana HMA2 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays an important role in zinc transport and homeostasis. Could also be involved in cadmium detoxification.
Gene References into Functions
  1. The molecular structures of zinc-binding- HMA4 and -HMA7 proteins have been determined and compared in order to provide insights into the structural basis for the differences in their metal binding properties. PMID: 19883117
  2. plant Zn2+-ATPase N-terminal metal binding domains (N-MBDs) have folding & function similar to Cu+-ATPase N-MBDs. unique Zn2+ coordination via two thiols and a carboxyl group provides selective binding of the activating metals to these regulatory domains PMID: 17550234
  3. observations suggest that the N-terminal domain of HMA2 is essential for function in planta while the C-terminal domain, although not essential for function, may contain a signal important for the subcellular localization of the protein. PMID: 19076719
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily
Tissue Specificity
Predominantly expressed in the vascular tissues of roots, stems, and leaves. Also detected in developing anthers.
Database Links

KEGG: ath:AT4G30110

STRING: 3702.AT4G30110.1

UniGene: At.31858

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