inv Antibody

Code CSB-PA356540XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) inv Polyclonal antibody
Uniprot No.
Target Names
inv
Alternative Names
inv antibody; CG17835 antibody; Homeobox protein invected antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) inv protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Engrailed (en) and invected (inv) are functionally redundant transcription factors in neuronal precursor cell NB5-3 specification. Inv is unable to substitute for en in other regulatory processes such as maintaining gsb expression in the neuroectoderm after stage 10 of embryogenesis. Maintenance of gsb expression in row 5 of the neuroectoderm involves an as yet unidentified short range signaling molecule.
Gene References into Functions
  1. Data indicate there is redundancy in both regulatory DNA and protein function in invected (inv) and engrailed (en) genes. PMID: 25172431
  2. Invected contributes to the auditory response to 200 Hz tones. PMID: 23940751
  3. cohesin helps restrain transcription of enhancer of split and invected-engrailed, and that deregulation of similarly cohesin-hypersensitive genes may underlie developmental deficits in Cornelia de Lange syndrome PMID: 19587787
Subcellular Location
Nucleus.
Protein Families
Engrailed homeobox family
Tissue Specificity
Expressed in row 6/7 of the embryonic neuroectoderm.
Database Links

KEGG: dme:Dmel_CG17835

STRING: 7227.FBpp0087173

UniGene: Dm.2797

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