oc Antibody

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Code	CSB-PA326346XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) oc Polyclonal antibody

Uniprot No.

P22810

Target Names

Alternative Names

oc antibody; Otd antibody; CG12154Homeotic protein ocelliless antibody; Protein orthodenticle antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) oc protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors.

Gene References into Functions

Our results indicate that the head-specific gap gene empty spiracles can act as a repressor of Toy, while ocelliless (oc) and spalt major (salm) appear to act as positive regulators of toy gene expression PMID: 26976323
Otd is a main component of the gene regulatory network that regulates synaptic-column and layer targeting in the fly visual system. PMID: 26114289
The conserved homeobox protein Orthodenticle acts together with the ecdysone receptor to directly repress the expression of Kruppel homolog 1. PMID: 22547825
Orthodenticle is expressed in a group of clonally related dopamine neurons from first instar larvae to adulthood, making it possible to establish an identity relationship between larval and adult dopamine neuron clusters. PMID: 21999236
Sequence analysis indicates that many of the transcriptional regulatory domains identified here are conserved in multiple Diptera Otd-related proteins. PMID: 20732315
Although Otd and Pph13 have been implicated in rhabdomere morphogenesis, we demonstrate that it is necessary to remove both factors to completely eliminate rhabdomere formation. PMID: 20667913
Mutational inactivation of otd/Otx2 and unpg/Gbx2 result in the loss or misplacement of the brain-specific expression domains of Pax2/5/8 and Hox genes. PMID: 12702651
Otd is a key player in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin expression PMID: 12967559
Otd as a critical regulator of photoreceptor morphology and phototransduction PMID: 18241855
Data show that otd/Otx gene is involved in the specification of the anterior brain during embryonic CNS development in Drosophila. PMID: 18683636

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Subcellular Location

Nucleus.

Protein Families

Paired homeobox family

Tissue Specificity

Expressed in the anterior region of the embryo before cellularization and becomes localized to the procephalic head region following gastrulation. These cells correspond to the mesectoderm or midline neuroepithelium and will generate a mixed population of

Database Links

KEGG: dme:Dmel_CG12154

STRING: 7227.FBpp0304126

UniGene: Dm.2933

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