HO Antibody

Datasheet

Code	CSB-PA357811XA01SVG
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Target Background

Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) HO Polyclonal antibody

Uniprot No.

P09932

Target Names

Alternative Names

HO antibody; YDL227CHomothallic switching endonuclease antibody; Ho endonuclease antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) HO protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Initiation of mating type interconversion. This protein is a site-specific endonuclease that cleaves a site in the mat locus on chromosome III. The double-strand break is followed by a unidirectional gene conversion event that replaces the information at the mat locus by information copied from either of the two homologous loci (HMR and HML) that reside at the extremity of the chromosome III. Endonuclease expression takes place in late G1 just before cells enter S phase.

Gene References into Functions

HO promotor region fires in an "on/off" fashion in WT cells as well as in different genetic backgrounds. PMID: 23836672
Analysis of MATalpha2 and MATa1 binding sites on the HO promotor that mediate repression of the HO gene. PMID: 15598821
DDI1 participates in MEC1-mediated degradation of HO. PMID: 15964793
ho endonuclease nuclear import utilizes two nuclear localization signals and four importins of the ribosomal import system PMID: 16507575
SWI/SNF, either directly or indirectly, facilitates TATA Binding Protein binding at HO. PMID: 16705163
Nuclear export of Ho endonuclease of yeast via Msn5 PMID: 18807043
Data show that coactivators bind first to far upstream promoter regions of HO and subsequently to a promoter proximal region, and FACT and Asf1 are both required for this coactivator re-recruitment. PMID: 19481521

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Subcellular Location

Nucleus.

Database Links

KEGG: sce:YDL227C

STRING: 4932.YDL227C

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HO Antibody

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