HOS2 Antibody

Code CSB-PA346819XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) HOS2 Polyclonal antibody
Uniprot No.
Target Names
HOS2
Alternative Names
HOS2 antibody; YGL194C antibody; G1330 antibody; Probable histone deacetylase HOS2 antibody; EC 3.5.1.98 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) HOS2 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation.
Gene References into Functions
  1. These results uncover an unexpected role for histone deacetylases (Rpd3 and Hos2) in promoting Spt6 interaction with elongating Pol II. PMID: 25182531
  2. observed the formation of a reversible cytosolic "stationary-phase granule" by Hos2, a nuclear histone deacetylase. In the stationary phase, hos2 mutants display reduced viability. PMID: 22337769
  3. both Elp3-induced acetylation and Hos2-induced deacetylation influence the nucleosome positions in the promoters of 24 genes PMID: 21297980
  4. Hos2 and Set3 function at tRNA genes to promote Ty1 integration PMID: 16415356
  5. Two histone deacetylases, RPD3 and HOS2, are required for the activation of DNA damage-inducible genes RNR3 and HUG1. PMID: 17296735
  6. the Hos2p/Set3p complex (SET3C) is a novel component critical for cell survival in response to secretory stress. PMID: 18487345

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Subcellular Location
Nucleus.
Protein Families
Histone deacetylase family, HD type 1 subfamily
Database Links

KEGG: sce:YGL194C

STRING: 4932.YGL194C

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