HOT1 Antibody

1. results presented in this work demonstrate that Hot1 enrichment is not detected through the coding regions of its target genes and rule out a direct role in transcription elongation PMID: 27480106
2. Hot1 is essential for transcription of just one gene, STL1. Hot1 may represent a class of transcription factors that are essential for transcription of a very few genes or even just one. PMID: 25904326
3. the C-terminal region, which corresponds to amino acids 610-719, is the DNA-binding domain of Hot1, which recognizes sequence 5'-GGGACAAA-3' located in the promoter of gene STL1. Similar sequences are found in the promoters of other Hot1 targets. PMID: 26470684
4. Single-cell gene expression analysis reveals altered activation of Hot1-targeted STL1 in ck2 mutants, resulting in a bimodal to unimodal shift in expression. PMID: 24817120
5. Expression of Yhr087wp under high glucose concentration is controlled by Hot1p and Sko1p transcription factors, which bind to its promoter. PMID: 22720784
6. effect of SCH9 on HOT1 stimulated recombination PMID: 15349770
7. HOT1 recombination phenotypes observed in deg1 mutants are caused by Pus3p's ability to modulate frameshifting and readthrough events during translation PMID: 16231152

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KEGG: sce:YMR172W

STRING: 4932.YMR172W