hb Antibody

1. Hunchback (Hb) regulates a significant number of genes that are expressed during late differentiation stages. Hb is expressed in two polyploid subperineurial glia cells (carpet cells) and a thorough functional analysis shows that loss of Hb function results in a loss of carpet cells in the eye-antennal disc. PMID: 29360820
2. Study concludes that hunchback (Hb) functions in progenitors (neuroblasts/GMCs) to establish heritable neuronal identity that is maintained by a Hb-independent mechanism. PMID: 28137283
3. Authors developed a simple model of hb transcription mid-blastula transition (MBT); model provides a clear dynamical picture of hb transcription regulation as one of the many, actively regulated events concurrently taking place during the MBT. PMID: 27172244
4. Hb bifunctionally regulates eve stripe 7, but it executes these two activities on different pieces of regulatory DNA--it activates the eve2+7 enhancer and represses the eve3+7 enhancer PMID: 25564665
5. The expression of Hunchback in the neuroblast increases over time and the absolute levels of its expression specify two different Crustacean-cardioactive-peptide neuronal fates. PMID: 25344076
6. The stripe enhancer is crucial for establishing the definitive border of the anterior Hb expression pattern during embryogenesis. PMID: 23122844
7. The nested DNA elements contained in HG4-1, HG4-3, and HG4-7 all possess the cis-regulatory DNA necessary for proper temporal hunchback expression in newly-formed neuroblasts. PMID: 22033538
8. Dan/Danr and Svp act in parallel pathways to limit Hb expression and allow neuroblasts to transition from making early-born neurons to late-born neurons at the proper time. PMID: 21429984
9. The present results suggest that hunchback is essential for male-typical shaping of the contralateral neurites by fruitless gene. PMID: 21471381
10. WT (self-regulatory) Hb output noise is predominantly dependent on the transcription and translation dynamics of its own expression, rather than on Bcd fluctuations. PMID: 21304932
11. Data propose that Hunchback maintains early neuroblast competence by silencing a suite of late-expressed genes. PMID: 20335359
12. an important player in sequential cell fate specification within the Drosophila CNS. PMID: 11861485
13. homologous domains from the TRPS-1 and Drosophila Hunchback proteins support homodimerization, but not heterodimerization with Ikaros PMID: 12620233
14. Results suggest that the differential regulation of Hunchback is achieved by a mechanism that integrates information created by the asymmetric distribution of Seven-up and Prospero. PMID: 16396905
15. At low concentrations, Hb activates gene expression, whereas at high concentrations it mediates repression in the Drosophila embryo. PMID: 18287046
16. quantified the dynamics of hb gene expression in flies that were wild-type, were mutant for hb self-regulation or Bcd binding, or contained an artificial promoter construct consisting of six Bcd and two Hb sites PMID: 18818726

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KEGG: dme:Dmel_CG9786

STRING: 7227.FBpp0081431

UniGene: Dm.1105