Ephx2 Antibody

1. Data suggest that significant dietary potassium (here, even as a single meal) increases postprandial effects that reduce sEH activity in blood by mechanisms involving insulin secretion and gut microbiota; these mechanisms combat oxidative stress and prevent cardiovascular diseases. PMID: 28863368
2. Prophylactic treatment with sEH inhibitors decreased myocardial damage due to ischemia reperfusion, hypertension and diabetes, and decreased endothelial dysfunction created by diabetes and hypertension. PMID: 28296232
3. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PMID: 25659109
4. The results suggest Ephx2 participation in the control of the vascular tone changes in kidney promoting the hypertensive state in the ISIAH rats. PMID: 25509856
5. Soluble epoxide hydrolase probably plays an important role in the development of hypertension in the rat models of renovascular hypertension. The activation of PPAR-gamma and RAAS by renal arterial stenosis are associated with sEH upregulation. PMID: 22178827
6. Inhibition of soluble epoxide hydrolase slows the progression of hyperglycemia and provides cardioprotection. PMID: 22865388
7. Programmed blood pressure-lowering effects of perinatal SEH inhibition cannot be only explained by persistent reduction in renal SEH activity but rather by more complex interactions between the renal SEH, lipoxygenase, and cyclooxygenase pathways. PMID: 21266668
8. Epoxide hydrolase inhibitors displays antihypertensive effects in Ren-2 transgenic rats with inducible malignant hypertension via an improvement of renal function. PMID: 21078594
9. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. PMID: 21164107
10. Soluble epoxide hydrolase enzyme (SEH) inhibition or Ephx2 gene deletion antagonizes neointimal formation in vivo by mechanisms that are endothelium dependent. SEH inhibition may have therapeutic potential for flow-induced remodeling. PMID: 20035028
11. Epoxide hydrolase plays a role in the regulation of blood pressure PMID: 11882632
12. Polymorphism in Ephx2 is not likely to contribute to blood pressure levels in spontaneously hypertensive rats. PMID: 12364351
13. AP-1 activation is involved in the transcriptional up-regulation of sEH by angiotensin II (Ang II) in endothelial cells, which may contribute to Ang II-induced hypertension PMID: 17495027
14. Linkage analyses with genome-wide expression profiling identified Ephx2 as a heart failure susceptibility gene in SHHF rats. PMID: 18443590
15. protein level of sEH was elevated in the heart of both spontaneously hypertensive rats and Ang II-infused Wistar rats PMID: 19126686

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KEGG: rno:65030

STRING: 10116.ENSRNOP00000023385

UniGene: Rn.54495