rst Antibody

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Code	CSB-PA600070XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) rst Polyclonal antibody

Uniprot No.

Q08180

Target Names

rst

Alternative Names

rst antibody; CG4125 antibody; Irregular chiasm C-roughest protein antibody; Protein IRREC antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) rst protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Required for correct axonal pathway formation in the optic lobe and for programmed cell death in the developing retina.

Gene References into Functions

The data reveal a novel requirement for Sac1 in promoting microtubule stability and suggest that Rst trafficking occurs in a microtubule- and exocyst-dependent manner. PMID: 29752385
the roles of Rst, Hbs, Kirre and SNS in the spacing of bristles of the anterior wing margin, are explored. PMID: 26053791
Cindr recapitulates both proposed functions of its mammalian orthologs Cd2ap and Cin85: targeting the IgCAMs Rst and Hbs for endocytosis and stabilizing these heterophilic IgCAM complexes. PMID: 23027549
Analysis of a cytoplasmic motif present in Kirre and IrreC/Rst revealed a functionally required, conserved 12 AA motif (KIN1 motif). PMID: 22792268
Findings suggest a general mechanism by which rst and kirre expression could be fine tuned to optimize their redundant roles during development. PMID: 21857931
identified two cell-adhesion molecules: Hibris, which is expressed in post-mitotic lamina precursor cells; and Roughest, which is expressed on retinal axons. PMID: 20724453
A novel relationship is described between the Crumbs partner beta(Heavy)-spectrin (beta(H)), the zona adherens and Roughest. PMID: 20048344
rst gene has a role in the differentiation of secondary/tertiary pigment cell fate PMID: 12782271
Roughest (Rst) is a cell adhesion molecule of the immunoglobulin superfamily with pleiotropic functions during the development of Drosophila melanogaster. PMID: 15278452
The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila PMID: 16380111
describe the expression pattern and of Rst in wild type and rst(D) mutants, showing that downregulation in salivary glands at the beginning of pupal stage is an important factor in implementation of the autophagic program of this tissue in space and time PMID: 19415632

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Postembryonic expression is strong in the developing optic lobe and in the eye imaginal disk.

Database Links

KEGG: dme:Dmel_CG4125

STRING: 7227.FBpp0070537

UniGene: Dm.1692

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rst Antibody

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