infC Antibody

Datasheet

Code	CSB-PA015166XA01ENV
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Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) infC Polyclonal antibody

Uniprot No.

P0A707

Target Names

infC

Alternative Names

infC antibody; fit antibody; srjA antibody; b1718 antibody; JW5829 antibody; Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3 antibody; N-terminally processed; Translation initiation factor IF-3S] antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) infC protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

One of the essential components for the initiation of protein synthesis.IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.

Gene References into Functions

The C-terminal domain of infC is essential for growth and the N-terminal domain adds to the fidelity of initiation of protein synthesis and to the fitness of the bacterial growth. PMID: 28320882
These results strongly support a conformational selection model in which the conformation of IF3 that is selectively stabilized within a completely and correctly assembled 30S IC facilitates further progress along the initiation pathway. PMID: 23584454
The importance of IF3 in the overall mechanism of ribosome recycling in E.coli. PMID: 16199751
dynamic binding path of IF3 on the 30S subunit and its release upon 30S-50S association PMID: 17244535
Study shows that after cold shock two promoters are activated resulting in de novo infC transcription and IF3 synthesis resulting in IF3/ribosomes ratio that contributes to establishing the cold-shock translational bias. PMID: 17592046
overexpression of IF3 led to a marked decrease in re-initiation efficiency, suggesting that a 30S ribosome and not a 70S ribosome is used for translation re-initiation PMID: 18221266

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Subcellular Location

Cytoplasm.

Protein Families

IF-3 family

Database Links

KEGG: ecj:JW5829

STRING: 316407.1742797

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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infC Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background