TIF5 Antibody

Code CSB-PA007572XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TIF5 Polyclonal antibody
Uniprot No.
Target Names
TIF5
Alternative Names
TIF5 antibody; YPR041W antibody; YP3085.05Eukaryotic translation initiation factor 5 antibody; eIF-5 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TIF5 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). eIF-5 is essential for cell viability.
Gene References into Functions
  1. eIF2B has a second activity as a GDI displacement factor (GDF) that can recruit eIF2 from the eIF2*GDP/eIF5 GDI complex prior to GEF action. PMID: 24352424
  2. eIF5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation. PMID: 15964804
  3. Data suggest strongly that the interaction between eIF5 and eIF1A is involved in maintaining the fidelity of start codon AUG recognition in vivo. PMID: 16380131
  4. Results describe the 1.5A crystal structure of eukaryotic initiation factor eIF5 C terminal domain, confirming that eIF5-CTD contains an atypical HEAT motif. PMID: 16616930
  5. eIF-5 can form the multifactor complex with the ribosome 40S subunit. PMID: 17389391
  6. The direct interaction at eIF1 places eIF5 near the decoding site of the 40 S subunit. PMID: 17974565

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Protein Families
EIF-2-beta/eIF-5 family
Database Links

KEGG: sce:YPR041W

STRING: 4932.YPR041W

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