Ttc26 Antibody

Code CSB-PA803927XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Ttc26 Polyclonal antibody
Uniprot No.
Target Names
Ttc26
Alternative Names
Ttc26 antibody; Hop antibody; Ift56 antibody; Intraflagellar transport protein 56 antibody; Protein hop-sterile antibody; Tetratricopeptide repeat protein 26 antibody; TPR repeat protein 26 antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Ttc26 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.
Gene References into Functions
  1. These studies define a distinct and novel role for IFT56 in IFTB complex integrity that is crucial for cilia structure and function and, ultimately, animal development. PMID: 28264835
  2. Data show that Hop is expressed in airway epithelium coincident with HDAC2, and acts downstream of Nkx2.1 and GATA6, to negatively regulate surfactant protein expression. PMID: 16510470
  3. TTC26 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. PMID: 24596149
  4. Our analysis of the hop mouse line provides novel insights into Hh signaling, demonstrating that Ttc26 is necessary for efficient coupling between the accumulation of Gli at the ciliary tip and its dissociation from Sufu. PMID: 25340710
Subcellular Location
Cell projection, cilium.
Protein Families
IFT56 family
Tissue Specificity
High expression detected in testis. Detected also retina, kidney, lung and brain tissue. The expression level is low in liver and spleen. Present in the airway epithelial cells and the testes (at protein level).
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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