SRP1 Antibody

Code CSB-PA209629XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SRP1 Polyclonal antibody
Uniprot No.
Target Names
SRP1
Alternative Names
SRP1 antibody; KAP60 antibody; YNL189W antibody; N1606 antibody; Importin subunit alpha antibody; Karyopherin subunit alpha antibody; Karyopherin-60 antibody; Serine-rich RNA polymerase I suppressor protein antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SRP1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Functions in nuclear protein import as an adapter protein for importin beta nuclear receptors. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Together with importin beta KAP95, mediates nuclear import of transcription factor GCN4. Together with tethering factor STS1, targets the proteasome to the nucleus.
Gene References into Functions
  1. binding of Yar1 to one N-domain and binding of Kap60 to the second N-domain of dimerized Rps3 orchestrates import and protection of the ribosomal protein PMID: 27819319
  2. Srp1 has a role in performing distinct roles in the import of nuclear proteins and in targeting proteasomes to the nucleus PMID: 25274630
  3. This report provides the first evidence that isoforms of Kap60 exist in yeast, and these isoforms participate in the molecular sorting and enrichment of inner nuclear membrane proteins to the nuclear envelope. PMID: 20846261
  4. These results reveal that the classical nuclear protein import pathway makes important contributions to the G(1)/S cell cycle transition. PMID: 18984568
Subcellular Location
Cytoplasm, perinuclear region. Note=Mainly localized at the periphery of the nucleus.
Protein Families
Importin alpha family
Database Links

KEGG: sce:YNL189W

STRING: 4932.YNL189W

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