ImpL2 Antibody

Code CSB-PA285282XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) ImpL2 Polyclonal antibody
Uniprot No.
Target Names
ImpL2
Alternative Names
ImpL2 antibody; CG15009 antibody; Neural/ectodermal development factor IMP-L2 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) ImpL2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion.
Gene References into Functions
  1. Increased expression of the secreted insulin/IGF antagonist ImpL2 is associated with organ wasting. PMID: 25850671
  2. Increased expression of ImpL2 is associated with cachexia-like wasting. PMID: 25850672
  3. Imp-L2-expressing neurons sense the nutritional state of Drosophila larvae and coordinate dietary information and ecdysone production to adjust developmental timing under starvation conditions PMID: 23773803
  4. role in the longevity PMID: 21108726
Subcellular Location
Secreted, extracellular space.
Tissue Specificity
Detected in several sites including the ventral neuroectoderm, the tracheal pits, the pharynx and esophagus, and specific neuronal cell bodies, where it is primarily expressed.
Database Links

KEGG: dme:Dmel_CG15009

STRING: 7227.FBpp0073106

UniGene: Dm.2799

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