Actbeta Antibody

Code CSB-PA526456XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Actbeta Polyclonal antibody
Uniprot No.
Target Names
Actbeta
Alternative Names
Actbeta antibody; activin-beta antibody; CG11062 antibody; Inhibin beta chain antibody; Activin beta chain antibody; dAct antibody; dActivin antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Actbeta protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain.
Gene References into Functions
  1. a conserved role for activin in enhancing adipokinetic hormone/glucagon signaling and glycemic control, is reported. PMID: 28178568
  2. These data reveal how insulin signaling can regulate aging through control of Activin signaling that in turn controls autophagy, representing a potentially conserved molecular basis for longevity assurance PMID: 24244197
Subcellular Location
Secreted.
Protein Families
TGF-beta family
Tissue Specificity
Widely expressed in larval brains.
Database Links

KEGG: dme:Dmel_CG11062

STRING: 7227.FBpp0088273

UniGene: Dm.5732

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