INO2 Antibody

1. corepressors may be recruited not only by repressors but also by activators such as Ino2. Indeed, we could demonstrate direct interaction of Ino2 with Sin3 and Cyc8. The Opi1 repressor interaction domain within Ino2 is also able to contact Sin3 and Cyc8. PMID: 28175933
2. Upon induction, Ino2p dissociates from the INM1 promoter. PMID: 25211324
3. Cbf1p binding to the upstream sites was required for the binding of the ISW2 chromatin-remodeling complex to the Ino2p-Ino4p-binding sites on the INO1 promoter. PMID: 20935143
4. Factors required for activation of yeast phospholipid biosynthetic genes depend on activator protein Ino2 which binds to the inositol/choline-responsive element. PMID: 20054697
5. Ino2p activator is required for histone acetylation. PMID: 20018175
6. Genes containing the UASINO sequence were bound by Ino2p. PMID: 15611057
7. Gene repression occurs in the presence of sufficient inositol and choline, requiring an intact Opi1 repressor which binds to Ino2, we mapped an 18 aa repressor interaction domain within Ino2 necessary and sufficient for binding by Opi1. PMID: 15819625
8. Autoregulatory expression of INO2, INO4 and OPI1 was abolished by promoter exchange experiments, showing that autoregulation of regulators contributes to the degree of differential gene expression but is not responsible for it. PMID: 18542964

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KEGG: sce:YDR123C

STRING: 4932.YDR123C