InR Antibody

1. a sensory neuron-specific function of InR regulates the persistence of injury-associated hypersensitivity. PMID: 29752280
2. Impairment of insulin signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva.[Insulin] PMID: 22786647
3. it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals. PMID: 29372799
4. Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor. PMID: 26020640
5. Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress PMID: 25937233
6. results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep PMID: 25581915
7. This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress. PMID: 25966593
8. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling. PMID: 23935447
9. InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation. PMID: 24026119
10. Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis PMID: 23022298
11. controls growth and size by modulating PtdInsP(3) levels. PMID: 12163412
12. required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system; functions as a guidance receptor for the adapter protein Dock/Nck PMID: 12702880
13. InR regulates cell growth and proliferation through the dP13K/dAkt pathway. PMID: 12893776
14. Genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. PMID: 15592467
15. insulin-like receptor pathway incorporates 4E-BP resistant cellular IRES containing mRNAs to functionally couple transcriptional activation with differential translational control in a cell that is otherwise translationally repressed by 4E-BP PMID: 17234883
16. InR/Foxo signaling controls cell cycle progression by modulating dmyc expression and dMyc transcriptional activity PMID: 19211682
17. In Drosophila melanogaster the level and pattern of variation at the 8-kb region of InR surveyed did not provide any indication of a recent selective event in this region. PMID: 19398492

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KEGG: dme:Dmel_CG18402

STRING: 7227.FBpp0288669

UniGene: Dm.1271