IntS12 Antibody

Code CSB-PA436635XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) IntS12 Polyclonal antibody
Uniprot No.
Target Names
IntS12
Alternative Names
IntS12 antibody; CG5491 antibody; Integrator complex subunit 12 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) IntS12 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Required for the normal expression of the Integrator complex component IntS1. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
Gene References into Functions
  1. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex PMID: 23288851
Subcellular Location
Nucleus.
Protein Families
Integrator subunit 12 family
Database Links

KEGG: dme:Dmel_CG5491

STRING: 7227.FBpp0084433

UniGene: Dm.6375

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