Asun Antibody

Code CSB-PA894682XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Asun Polyclonal antibody
Uniprot No.
Target Names
Asun
Alternative Names
Asun antibody; IntS13 antibody; Mat89Bb antibody; ovary2 antibody; CG6814 antibody; Protein asunder antibody; Cell cycle regulator Mat89Bb antibody; Integrator complex subunit 13 antibody; Maternal transcript 89Bb antibody; Set apart in position or space protein antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Asun protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. Plays a role as a regulator of spermatogenesis. Crucial regulator of the mitotic cell cycle and development. Required for the correct dynein-dynactin perinuclear localization important for nucleus-centrosome coupling that occur upon meiotic progression of primary spermatocytes. Plays a role in sperm motility and fertility. May have a role in the PNG/PLU/GNU pathway.
Gene References into Functions
  1. ASUN is identified as a functional component of Integrator (INT), a multisubunit complex required for 3'-end processing of small nuclear RNAs. PMID: 23904267
  2. asun is a critical regulator of dynein localization and dynein-mediated processes during Drosophila oogenesis PMID: 24333177
  3. asunder(previously Mat89Bb)required for male fertility; asun spermatocytes & spermatids exhibit reduction of perinuclear dynein-dynactin; model proposed in which asun coordinates spermatogenesis by promoting dynein-dynactin recruitment to nuclear surface PMID: 19357193
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
Protein Families
Asunder family
Tissue Specificity
Expressed in nurse cells at stages 9-10 of oogenesis and exported to the oocyte. Also expressed in the follicle cells surrounding the oocyte.
Database Links

KEGG: dme:Dmel_CG6814

STRING: 7227.FBpp0082713

UniGene: Dm.2414

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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