ipaA Antibody

Code CSB-PA323559XA01SZB
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Product Details

Full Product Name
Rabbit anti-Shigella flexneri ipaA Polyclonal antibody
Uniprot No.
Target Names
ipaA
Alternative Names
ipaA antibody; CP0125 antibody; Invasin IpaA antibody; 70 kDa antigen antibody
Raised in
Rabbit
Species Reactivity
Shigella flexneri
Immunogen
Recombinant Shigella flexneri ipaA protein
Immunogen Species
Shigella flexneri
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Rapidly associates with the first 265 amino acids of vinculin after bacteria-cell contact. This interaction is critical for efficient Shigella uptake. IpaA acts as a potent activator of vinculin and increase its ability to interact with F-actin. The complex IpaA-vinculin induces F-actin depolymerization along with the occasional formation of actin filament bundles.
Gene References into Functions
  1. IpaA has two alpha-helical vinculin-binding sites that simultaneously bind two VD1 molecules. PMID: 16826238
Subcellular Location
Secreted. Note=Secreted through the specialized type-III secretion system Mxi/Spa from the bacterium through the cell cytosol.
Protein Families
SipA/IpaA family
Database Links

KEGG: sfl:CP0125

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