IPL1 Antibody

1. Decatenation and condensation defects lead to spindle stabilization during cytokinesis, allowing bridge detection by Aurora B. PMID: 27111841
2. Shedding is regulated by the conserved protein kinase Ipl1/Aurora-B and promotes the subsequent assembly of a kinetochore. PMID: 26157162
3. increase in Aurora B activity causes premature collapse of the mitotic spindle by promoting instability of the spindle midzone. PMID: 25201961
4. a novel and unexpected role for Aurora kinase in preventing the formation of spindles by Clb5-CDK (S-CDK) during meiotic prophase I PMID: 24386320
5. protein phosphatase-1 and aurora protein kinase suppressors PMID: 23894419
6. results suggest that activation of Aurora B kinase (Ipl1) by clustering either on chromatin or on microtubules is sufficient for chromosome biorientation PMID: 23604256
7. The Ipl1/Aurora-dependent phosphorylation of Sli15 controls spindle function by excluding the CPC from spindle regions engaged in microtubule polymerization. PMID: 21727193
8. Although the Dam1 kinetochore complex has been implicated as a key downstream target, we found the existence of unidentified Ipl1 sites on Dam1 or additional important substrates that regulate both microtuble detachment and the checkpoint. PMID: 16327780
9. The overexpression of Glc7 regulatory subunits can titrate Glc7 away from relevant Ipl1 targets and thereby suppress ipl1-321 cells by restoring the balance of phosphatase/kinase activity. PMID: 16537909
10. Study finds that the Aurora B kinase Ipl1 regulates kinetochore-microtubule attachment during both meiotic divisions and that a complex known as the monopolin complex ensures that the protein kinase coorients sister chromatids during meiosis I. PMID: 17289568
11. We suggest that centromeric Ipl1 ensures the continued centromeric presence of active Rts1/PP2A, which in turn locally protects cohesin and cohesion. PMID: 17371833
12. Tousled has a bona fide kinase-independent role in the activation of Aurora B kinases in vivo PMID: 18334486
13. Nbl1p colocalizes and copurifies with the chromosomal passenger complex PMID: 19158380
14. The budding Bim1p is regulated by Ipl1p-mediated multisite phosphorylation. Bim1p forms a stable complex with Ipl1p and is phosphorylated on a cluster of six Ser residues in the flexible linker connecting the calponin homology (CH) and EB1 domains. PMID: 19667128
15. Ipl1 coordinates changes to meiotic chromosome structure with resolution of crossovers and cell cycle progression at the end of meiotic prophase PMID: 19759266

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KEGG: sce:YPL209C

STRING: 4932.YPL209C