Ir21a Antibody

Code CSB-PA295330XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Ir21a Polyclonal antibody
Uniprot No.
Target Names
Ir21a
Alternative Names
Ir21a antibody; CG2657 antibody; Ionotropic receptor 21a antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Ir21a protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior.
Gene References into Functions
  1. The authors find that two Ionotropic Receptors, IR21a and IR25a, are required to mediate Dorsal Organ Cool Cell responses to cooling and are required for cool avoidance behavior. PMID: 27126188
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Glutamate-gated ion channel (TC 1.A.10.1) family
Tissue Specificity
Expressed in the dorsal organ cool cells. In the antenna, expressed in approximately six neurons in the arista as well as five to ten neurons near the third chamber of the sacculus.
Database Links

KEGG: dme:Dmel_CG2657

STRING: 7227.FBpp0111921

UniGene: Dm.32762

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