IRT1 Antibody

1. Data suggest that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions. PMID: 27849020
2. role of IRT1 in iron uptake PMID: 25778985
3. Our results reveal a role of SNX1 for the correct trafficking of IRT1 and, thus, for modulating the activity of the iron uptake machinery PMID: 24596241
4. This work establishes a functional link between the dynamics and the lateral polarity of IRT1 and the transport of its substrates, and identifies a molecular mechanism driving polar localization of a cell surface protein in plants. PMID: 24843126
5. IDF1 directly regulates IRT1 degradation through its RING-type E3 ligase activity. PMID: 23995086
6. AtIRT1 transports nicekl (Ni(2+)) in roots, and strongly suggest that Ni accumulation is further accelerated by AtIRT1 that is expressed in response to excess Ni. PMID: 21742768
7. These data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 low to ensure proper iron uptake and to prevent metal toxicity. PMID: 21628566
8. IRT1 and FRO2 genes are upregulated under iron starvation. PMID: 21426424
9. Application of the lipoxygenase inhibitor ibuprofene to plants caused an up-regulation of IRT1 gene expression. PMID: 21334215
10. Although ferrous ions and other IRT1-transported metal ions do not bind very tightly, the Histidine-rich sequence has a very high entropy-driven affinity for Fe3+, which may have biological significance. PMID: 17029360
11. Expression of each of the IRT1 variants in plants from the 35S promoter revealed that K146 or K171 is required for iron-induced protein turnover, and 35S-IRT1K146R,K171R plants contain higher levels of iron compared to 35S-IRT1 and wild type PMID: 18305211
12. Acidification capacity varied among Arabidopsis accessions and was associated with a high induction of AHA2 and IRT1... PMID: 19549134

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KEGG: ath:AT4G19690

STRING: 3702.AT4G19690.2

UniGene: At.2319