iscA Antibody

1. deletion of IscA/SufA may disrupt the iron delivery for iron-sulfur cluster biogenesis, therefore impeding sulfur delivery by IscS, and result in the accumulation of red IscS in E. coli cells PMID: 25907559
2. Additional studies reveal that copper can compete with iron for the metal binding site in IscA and effectively inhibits the IscA-mediated iron-sulphur cluster assembly in Escherichia coli cells. PMID: 24946160
3. study finds IscA essential for iron-sulfur cluster assembly in E. coli under aerobic growth conditions; results provide evidence that IscA may act as an iron chaperone for the biogenesis of iron-sulfur clusters in E. coli under aerobic conditions PMID: 20942799
4. the thioredoxin reductase system mediates iron binding in IscA and iron delivery for the iron-sulfur cluster assembly in IscU PMID: 15985427
5. IscA recruits intracellular iron for the iron-sulfur cluster assembly under normal physiological conditions, whereas CyaY may serve as an iron chaperon to sequester redox active free iron under oxidative stress conditions PMID: 17244611
6. IscA may constitute the redundant cellular activities to recruit intracellular iron and deliver iron for the iron-sulfur cluster assembly in E. coli. PMID: 17941825
7. Results suggest that the biogenesis of the [4Fe-4S] and the [2Fe-2S] clusters may have distinct pathways and that IscA/SufA paralogues are essential for the [4Fe-4S] cluster assembly, but are dispensable for the [2Fe-2S] cluster assembly. PMID: 19309314

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KEGG: ecj:JW2512

STRING: 316385.ECDH10B_2695