iscU Antibody

1. We have demonstrated that a single mutation in the scaffold protein IscU rendered E. coli viability strictly dependent upon a functional CyaY. PMID: 25996492
2. Data indicate that the single point mutation IscU_D39A affects the 2Fe-2S coordination geometry. PMID: 25447544
3. Data indicate that IscU exists as two interconverting species: one (S) is largely structured with all four peptidyl-prolyl bonds trans; the other (D) contains an ordered domain that stabilizes two cis peptidyl-prolyl peptide bonds. PMID: 23333622
4. The iron-sulfur cluster assembly in E. coli IscU is an IscS mediated biosynthetic process. PMID: 22348472
5. study determined the crystal structures of IscS-IscU and IscS-TusA complexes providing the first insight into their different modes of binding and the mechanism of sulfur transfer PMID: 20404999
6. Thioredoxin reductase system mediates iron binding in IscA and iron delivery for the iron-sulfur cluster assembly in IscU PMID: 15985427
7. Escherichia coli CYaY is an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU PMID: 16603772

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KEGG: ecj:JW2513

STRING: 316385.ECDH10B_2696