mew Antibody

Code CSB-PA635520XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) mew Polyclonal antibody
Uniprot No.
Target Names
mew
Alternative Names
mew antibody; CG1771 antibody; Integrin alpha-PS1 antibody; Position-specific antigen subunit alpha-1 antibody; Protein multiple edematous wings) [Cleaved into: Integrin alpha-PS1 heavy chain; Integrin alpha-PS1 light chain] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) mew protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Integrin alpha-PS1/beta-PS is a receptor for laminin.
Gene References into Functions
  1. alphaPS1betaPS integrin controls salivary gland migration through Rac1 GTPase which downregulates E-cadherin in proximal and distal gland cells. PMID: 23500171
  2. Data indicate that alphaPS1betaPS integrin receptors regulate the amount and type of Sog fragments available for diffusion in the extracellular space and impact Dpp function during oogenesis and pupal wing development. PMID: 20017203
  3. interaction with gene encoding moleskin PMID: 12242240
Subcellular Location
Apical cell membrane; Single-pass type I membrane protein. Lateral cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Note=During mid-oogenesis, localizes to the apical, to the lateral and to the basal membranes of follicle cells. Apical membrane localization peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte while decreases in the most posterior follicle cells. Localization to lateral and basal membranes persists during dorsal appendage morphogenesis, although diminished and often absent.
Protein Families
Integrin alpha chain family
Tissue Specificity
Expressed in follicle cells (at protein level). At syncytial blastoderm stage, expressed in the ectoderm but not in the mesodermal precursors. At embryonic stage 7, expressed in dorsal and ventrolateral ectoderm and in some yolk nuclei. At late stage 10,
Database Links

KEGG: dme:Dmel_CG1771

STRING: 7227.FBpp0302767

UniGene: Dm.152

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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