mys Antibody

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Code	CSB-PA319315XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) mys Polyclonal antibody

Uniprot No.

P11584

Target Names

mys

Alternative Names

mys antibody; l(1)mys antibody; olfC antibody; CG1560 antibody; Integrin beta-PS antibody; Position-specific antigen beta subunit antibody; Protein myospheroid antibody; Protein olfactory C antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) mys protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip. Plays a role in timely border cell migration during oogenesis.

Gene References into Functions

analysis of integrin beta subunit mutations that alter affinity for extracellular matrix ligand PMID: 21757698
Dei's expression is restricted to intervein territories where it acts as a potent activator of betaPS integrin expression PMID: 21215259
Study finds that the integrin subunit Mys is required only for monolayer formation; these results indicate that collapse, spreading and monolayer formation are not only temporally distinct, but also probably molecularly distinct. PMID: 20530544
mutation of betaPS integrin subunit has dominant negative properties in developing Drosophila PMID: 11950944
Delayed behavioral aging is influenced by the beta-integrin protein (betaPS). PMID: 14570233
The C8-C9 loop of the betaPS subunit contains structural information that can differentially regulate integrin activity. PMID: 14980507

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Subcellular Location

Apical cell membrane; Single-pass type I membrane protein. Lateral cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Note=In ovary, localizes to the apical, lateral and basal membranes of follicle cells through oogenesis stage 10A. Apical membrane expression peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte but decreases in the most posterior follicle cells. Thereafter, it is down-regulated. Localization to lateral and basal membranes persists during dorsal appendage morphogenesis.

Protein Families

Integrin beta chain family

Tissue Specificity

In ovaries, strongly expressed in follicle cells. In oocytes, expressed in the forming dorsal appendages (at protein level). Expressed in the embryonic dorsal cuticle, the larval eye and the wing imaginal disk. In testes, detected at the interface between

Database Links

KEGG: dme:Dmel_CG1560

STRING: 7227.FBpp0071061

UniGene: Dm.1814

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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mys Antibody

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