Itpr Antibody

1. slow imaginal disc intercellular calcium waves (SIDICs) are mediated by the inositol-3-phosphate receptor, the endoplasmic reticulum (ER) calcium pump SERCA and the key gap junction component Inx2. PMID: 27503836
2. Study found that phototransduction was quantitatively unaffected not only after IP3R-RNAi, but also in IP3R-null mutants; describes novel phenotypes in photoreceptors from flies expressing the transcription factor (Gal4) used to drive RNAi expression. Results indicate that IP3R plays no significant role in Drosophila phototransduction while emphasizing the need for caution when using Gal4 drivers. PMID: 28660247
3. cell-specific regulation of protein synthesis by IP3R in neuroendocrine cells influences protein metabolism. PMID: 28289132
4. The present study shows that itpr function in peptidergic neurons is not only necessary but also sufficient for maintaining normal lipid metabolism in Drosophila. PMID: 24350669
5. InsP3R function alters lipid metabolism and causes hyperphagia. PMID: 23471909
6. Studies show that expression of transcripts related to carbohydrate and amine metabolism is altered in InsP(3) receptor mutant larvae. PMID: 21901161
7. Restoring InsP(3)R-mediated Ca(2+) release and SOCE in neuromodulatory cells influences systemic behaviors such as flight by regulating intracellular Ca(2+) homeostasis in a large population of neurons through a non-cell-autonomous mechanism. PMID: 20107057
8. ommatidia with a null mutation of IP(3)R degenerate by a process associated with intermittent lipid peroxidation and apoptotic activities PMID: 20404055
9. data support a model where InsP(3)R activity in non-overlapping neuronal domains independently rescues larval itpr phenotypes by non-cell autonomous mechanisms PMID: 19680544
10. Mutants of itpr, encoding inositol (1,4,5)-trisphosphate receptor (IP(3)R), attenuate response to diuretic peptides of Drosophila melanogaster renal (Malpighian) tubules PMID: 12547945
11. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene exhibit delays in molting while stronger alleles are also larval lethal. There is a critical period for itpr gene function in second instar larvae. PMID: 15020420
12. The InsP(3) receptor functions to modulate flight specifically through serotonergic interneurons. InsP(3) receptor action appears to be important for normal development of the flight circuit and its central pattern generator. PMID: 15356199
13. Results describe single channel properties of a point mutant (G2630S) in the pore-forming region of the Drosophila inositol (1,4,5)-trisphosphate receptor . PMID: 15388340
14. ectopic expression of the Ka901 mutant channel in aminergic cells alters electrophysiological properties of a flight circuit and results in defective flight behavior PMID: 16325255

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KEGG: dme:Dmel_CG1063

STRING: 7227.FBpp0078336

UniGene: Dm.4462