jhd1 Antibody

Code CSB-PA527238XA01SXV
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Product Details

Full Product Name
Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) jhd1 Polyclonal antibody
Uniprot No.
Target Names
jhd1
Alternative Names
jhd1 antibody; epe1 antibody; SPCC622.16c antibody; Putative JmjC domain-containing histone demethylation protein 1 antibody; EC 1.14.11.27 antibody; Heterochromatin-destabilizing protein epe1 antibody; [Histone-H3]-lysine-36 demethylase 1 antibody
Raised in
Rabbit
Species Reactivity
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Immunogen
Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) jhd1 protein
Immunogen Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May be a histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Represses transcriptional silencing by negatively affecting heterochromatin stability.
Gene References into Functions
  1. Bdf2 is enriched at IRCs through its interaction with the boundary protein Epe1. PMID: 24013502
  2. an interplay between the repressive HDACs activity and Epe1 helps to regulate gene expression PMID: 17449867
  3. Epe1 stabilises silent chromatin, preventing the oscillation of heterochromatin domains. The authors propose that Epe1 regulates heterochromatin assembly and disassembly . PMID: 17948055
Subcellular Location
Nucleus.
Protein Families
JHDM1 histone demethylase family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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