jhd1 Antibody

Code CSB-PA527238XA01SXV
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Product Details

Full Product Name Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) jhd1 Polyclonal antibody
Uniprot No. O94603
Target Names jhd1
Alternative Names jhd1 antibody; epe1 antibody; SPCC622.16c antibody; Putative JmjC domain-containing histone demethylation protein 1 antibody; EC antibody; Heterochromatin-destabilizing protein epe1 antibody; [Histone-H3]-lysine-36 demethylase 1 antibody
Raised in Rabbit
Species Reactivity Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Immunogen Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) jhd1 protein
Immunogen Species Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
May be a histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Represses transcriptional silencing by negatively affecting heterochromatin stability.
Gene References into Functions
  1. Bdf2 is enriched at IRCs through its interaction with the boundary protein Epe1. PMID: 24013502
  2. an interplay between the repressive HDACs activity and Epe1 helps to regulate gene expression PMID: 17449867
  3. Epe1 stabilises silent chromatin, preventing the oscillation of heterochromatin domains. The authors propose that Epe1 regulates heterochromatin assembly and disassembly . PMID: 17948055
Subcellular Location Nucleus.
Protein Families JHDM1 histone demethylase family
Database Links

KEGG: spo:SPCC622.16c

STRING: 4896.SPCC622.16c.1

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