unc-16 Antibody

Datasheet

Code	CSB-PA333918XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans unc-16 Polyclonal antibody

Uniprot No.

P34609

Target Names

unc-16

Alternative Names

unc-16 antibody; egl-39 antibody; ZK1098.10JNK-interacting protein antibody; JIP antibody; JNK MAP kinase scaffold protein antibody; Uncoordinated protein 16 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans unc-16 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Regulates the retrograde transport of autophagosomes from the neurites to the cell body of AIY interneurons.

Gene References into Functions

Data reveal a new and unprecedented role for 2 synapse assembly proteins, SAD-1 and SYD-2, in mediating UNC-16's organelle transport regulatory function. PMID: 26354976
an organelle gatekeeper model is suggested in which UNC-16 (JIP3/Sunday Driver) selectively inhibits the escape of Golgi and endosomal organelles from the axon initial segment. PMID: 23633144
These results support the possibility that UNC-16 acts as an adaptor that links kinesin-1 and dynein for anterograde transport of dynein, which mediates APL-1 retrograde transport. PMID: 21307258

Subcellular Location

Cytoplasm, perinuclear region. Note=Diffusely localized throughout cell body but intensely localized in regions adjacent to nucleus and at presumptive tips of neural processes.

Protein Families

JIP scaffold family

Tissue Specificity

Expressed in neurons of the ventral cord, retrovesicular and preanal ganglia and nerve ring, intestinal cells, seam and hypodermal cells, body wall, head muscle and pharynx.

Database Links

STRING: 6239.ZK1098.10e

UniGene: Cel.34202

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Service

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Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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unc-16 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background