jmjd6 Antibody

Code CSB-PA750866XA01DIL
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Product Details

Full Product Name Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) jmjd6 Polyclonal antibody
Uniprot No. Q6PFM0
Target Names jmjd6
Alternative Names jmjd6 antibody; psr antibody; ptdsr antibody; zgc:66264Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody; EC 1.14.11.- antibody; Histone arginine demethylase JMJD6 antibody; JmjC domain-containing protein 6 antibody; Jumonji domain-containing protein 6 antibody; Lysyl-hydroxylase JMJD6 antibody; Peptide-lysine 5-dioxygenase JMJD6 antibody; Phosphatidylserine receptor antibody; Protein PTDSR antibody; zfpsr antibody
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) jmjd6 protein
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as esr1. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation.
Gene References into Functions
  1. results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development PMID: 26924789
  2. PSR-dependent system in zebrafish embryos that engulfs apoptotic cells mediated by PSR-phagocytes during development, with the system assuming an important role in the normal development of tissues such as the brain, heart, notochord and somite PMID: 15469976
Subcellular Location Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm.
Protein Families JMJD6 family
Tissue Specificity After the somite segmentation period, it is apparent throughout the embryo and the hatching gland. At the larval (3 dpf) stage, it is detected in the heart and kidney.
Database Links

KEGG: dre:266962

STRING: 7955.ENSDARP00000107901

UniGene: Dr.86243

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