lid Antibody

1. However, for the N terminal region harboring both a PHD and an ARID finger, Lid anchors to the NuMat via both protein-protein and protein-DNA interactions. The association of JmjC domain with NuMat is the first report of the association of a demethylase domain with NuMat suggesting that Lid, a demethylase, being part of NuMat might be involved in regulating the chromatin dynamics via its NuMat association. PMID: 30207309
2. Analyses reveal KDM5 as a key regulator of larval growth and offer an invaluable tool for defining the biological activities of KDM5 family proteins. PMID: 29764901
3. Therefore Kdm5/Lid controls chromatin architecture in meiotic prophase I oocytes independently of its demethylase activity. PMID: 27494704
4. we demonstrate a direct, critical role for KDM5 in the activation of genes required for the integrity and functioning of mitochondria PMID: 26673323
5. KDM5 interacts with Foxo to modulate cellular levels of oxidative stress.KDM5 interacts with the lysine deacetylase HDAC4 to promote Foxo deacetylation, which affects Foxo DNA binding. PMID: 25329053
6. dKDM5/LID regulates Drosophila hematopoietic development PMID: 26183107
7. The results indicate that, at developmental genes, dKDM5/LID and ASH2 coordinately regulate H3K4me3 at the transcription-start site and that this dynamic regulation contributes to transcription. PMID: 22904080
8. These findings highlight the importance of Lid function in the regulated removal and recognition of histone H3 lysine 4 during development. PMID: 21124823
9. Lid knockdown using RNA interference results in a specific genome-wide increase in histone lysine methylation levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1. PMID: 17351630
10. Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate histone H3trimethyl-Lys4. PMID: 17351631
11. The finding that Lid antagonizes Rpd3 function provides an explanation for the genetic classification of Lid as a positive transcription regulator. PMID: 19114561

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KEGG: dme:Dmel_CG9088

STRING: 7227.FBpp0297914

UniGene: Dm.2779