KDM7A Antibody

Code CSB-PA747775XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KDM7A Polyclonal antibody
Uniprot No.
Target Names
KDM7A
Alternative Names
JHDM1D antibody; jmjc containing protein antibody; JmjC domain-containing histone demethylation protein 1D antibody; jumonji containing protein antibody; KDM7_HUMAN antibody; kiaa1718 antibody; Lysine-specific demethylase 7 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) KDM7A protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Gene References into Functions
  1. KDM7A mediates TNF-alpha-induced ICAM1 protein upregulation. PMID: 27565733
  2. G9a promotes H3K27 methylation of the E-cadherin promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene PMID: 26688070
  3. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
  4. increased JHDM1D expression suppresses tumor growth by down-regulating angiogenesis under nutrient starvation PMID: 22143793
  5. KIAA1718 is a dual-specificity histone demethylase that regulates neural differentiation through FGF4. PMID: 20084082

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Subcellular Location
Nucleus.
Protein Families
JHDM1 histone demethylase family, JHDM1D subfamily
Database Links

HGNC: 22224

KEGG: hsa:80853

STRING: 9606.ENSP00000380692

UniGene: Hs.308710

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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