Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans kgb-1 Polyclonal antibody

Uniprot No.

O44408

Target Names

kgb-1

Alternative Names

kgb-1 antibody; T07A9.3GLH-binding kinase 1 antibody; EC 2.7.11.24 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans kgb-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. Required for oogenesis and probably also for spermatogenesis. Involved in the response to environmental stress such as heavy metals, infection and protein folding stress in an age-dependent manner. In larvae, has a protective role which becomes detrimental in adults. May control susceptibility to infection, heavy metal stress and premature lethality by regulating daf-16 cellular localization. Involved in the transcriptional response to bacterial pore-forming toxins and to fasting. Required for fasting-induced longevity. Involved in axon regeneration after injury downstream of tyrosine receptor svh-2.

Gene References into Functions

These results identify FOS-1 as a transcriptional activator mediating age-invariant contributions of KGB-1. PMID: 27864060
KGB-1 promotes reproduction and lifespan and fosters gene expressions for AP-1 elements, protein biosynthesis, and balanced gametogenesis, but inhibits expressions for membrane transporters perhaps in order to control energy consumption PMID: 25500773
SHC-1 acts as a scaffold to link MAPKKK to MAPKK activation in the KGB-1 MAPK signal transduction pathway. PMID: 18809575

Subcellular Location

Cytoplasm.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily

Tissue Specificity

Expressed in somatic and germline tissues.

Database Links

KEGG: cel:CELE_T07A9.3

STRING: 6239.T07A9.3

UniGene: Cel.7426

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA246332XA01CXY
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

kgb-1 Antibody

Product Details

Customer Reviews and Q&A

Target Background