vab-8 Antibody

Code CSB-PA633664XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans vab-8 Polyclonal antibody
Uniprot No.
Target Names
vab-8
Alternative Names
vab-8 antibody; K12F2.2Kinesin-like protein vab-8 antibody; Variable abnormal morphology protein 8 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans vab-8 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for posterior migration of cells and axon growth cones during nervous system assembly.; Required for posterior migration of the axon growth cone and the ALM cell body. May enhance posterior migration by regulating the subcellular location or stability of guidance cue receptors such as sax-3 and unc-40, promoting their localization to the cell surface. In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of the gap junctions.; Specifically required for CAN cell migration.
Gene References into Functions
  1. VAB-8L directs cell and growth-cone migrations by promoting localization of guidance receptors to the cell surface. PMID: 17237778
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF26 subfamily
Tissue Specificity
Isoform a is expressed in the AVKR neuron. Isoform b is expressed in the CAN cells and in the body wall muscle. Also expressed in the motor neurons of the ventral nerve cord and additional neurons in the pharynx and head.
Database Links

KEGG: cel:CELE_K12F2.2

STRING: 6239.K12F2.2a

UniGene: Cel.6323

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