kin-20 Antibody

Code CSB-PA633618XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans kin-20 Polyclonal antibody
Uniprot No.
Target Names
kin-20
Alternative Names
kin-20 antibody; F46F2.2Casein kinase I isoform delta antibody; EC 2.7.11.1 antibody; Protein kinase 20 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans kin-20 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. Casein kinases are operationally defined by their preferential utilization of acidic proteins. Positively regulates the expression of components of the heterochronic pathway, which regulate developmental timing, such as the transcriptional repressor lin-42 and microRNAs such as let-7. Negatively regulates cell cycle exit and cell fusion to prevent the premature differentiation of hypodermal seam cells into adult cells. Plays a role in regulating axon branching and subsequently, the maturation of the nervous system, most likely by preventing the premature termination of transcripts for proteins such as Ankyrin/unc-44, which are required for maintaining the nervous system. May phosphorylate ssup-72 to promote nervous system maturation (Probable).
Gene References into Functions
  1. Worms containing a large deletion in kin-20 have a significantly smaller brood size and develop slower than wild type C. elegans. kin-20 is important for post-transcriptional regulation of mature let-7 and lin-4 microRNA expression. PMID: 29880558
Subcellular Location
Cytoplasm. Nucleus. Chromosome, centromere. Cell junction, adherens junction.
Protein Families
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Tissue Specificity
Expressed throughout larval development and into the adult stage in both hypodermal seam cells and the hermaphrodite specific neuron.
Database Links

KEGG: cel:CELE_F46F2.2

STRING: 6239.F46F2.2c.2

UniGene: Cel.996

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