pseT Antibody

Code CSB-PA361968XA01EDZ
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Product Details

Full Product Name
Rabbit anti-Enterobacteria phage T4 (Bacteriophage T4) pseT Polyclonal antibody
Uniprot No.
Target Names
pseT
Alternative Names
pseT antibody; Polynucleotide kinase antibody; PNK antibody; EC 2.7.1.78 antibody; Deoxynucleotide 3'-phosphatase antibody; EC 3.1.3.34 antibody; Polynucleotide 5'-hydroxyl-kinase antibody
Raised in
Rabbit
Species Reactivity
Enterobacteria phage T4 (Bacteriophage T4)
Immunogen
Recombinant Enterobacteria phage T4 (Bacteriophage T4) pseT protein
Immunogen Species
Enterobacteria phage T4 (Bacteriophage T4)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase. Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides. In the presence of ADP the enzyme also catalyzes an exchange reaction. In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP. Involved in countering a host defense mechanism which activates T4-induced anticodon nuclease and shuts off viral translation. The polynucleotide kinase modifies the ends of nicked tRNA generated by the antiviral response of the host bacteria and facilitates repair by T4 RNA ligase.
Gene References into Functions
  1. The G14D mutation impairs 5'-kinase activity in vivo as well as in vitro and leads to diminished processing at secondary sites of several RegB-cleaved transcripts. PMID: 23948816
  2. the degradation of RegB-cleaved mRNAs depends on a functional T4 polynucleotide kinase/phosphatase (PNK). The 5'-OH produced by RegB cleavage is phosphorylated by the kinase activity of PNK. PMID: 22499790
Database Links

KEGG: vg:1258796

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