knl-1 Antibody

Datasheet

Code	CSB-PA327305XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans knl-1 Polyclonal antibody

Uniprot No.

P34278

Target Names

knl-1

Alternative Names

knl-1 antibody; C02F5.1Kinetochore null protein 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans knl-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division. Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy. Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores. Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores.

Gene References into Functions

Data indicate that microtubule-associated proteins KNL-1 oligomerization may coordinate with other kinetochore activities to ensure the proper organization, function, and sensory capabilities of the kinetochore-microtubule attachment. PMID: 25411336
KNL-1 plays a central role in translating the initiation of kinetochore assembly PMID: 14522947

Subcellular Location

Cytoplasm, cell cortex. Chromosome, centromere, kinetochore.

Database Links

KEGG: cel:CELE_C02F5.1

STRING: 6239.C02F5.1

UniGene: Cel.7545

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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knl-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background