tpa-1 Antibody

Code CSB-PA339491XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans tpa-1 Polyclonal antibody
Uniprot No.
Target Names
tpa-1
Alternative Names
tpa-1 antibody; B0545.1 antibody; Protein kinase C-like 1 antibody; PKC antibody; EC 2.7.11.13 antibody; Tetradecanoyl phorbol acetate-resistant protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans tpa-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp-29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir-1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt, downstream of lin-3 and receptor let-23 and phospholipase plc-3.
Gene References into Functions
  1. In a screen for mutants that fail to express nlp-29 following fungal infection, alleles of tpa-1 were isolated, homologous to the mammalian protein kinase C (PKC) delta. PMID: 19380113
Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
Database Links

KEGG: cel:CELE_B0545.1

STRING: 6239.B0545.1a

UniGene: Cel.12259

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